I can make the main entrance run straight through the other side as like the actual museum with paths helping people through it.
If you look carefully at this picture you can see the glass pyramid on the other side of the building, I can make it like this no problem.

EDIT: Thanks Nek fo the help! Didn't realise I wasnt linking the image directly.
Also as Nek was saying I think this building would work best if the road system was made to incorporate it, not sure where I'll leave it to the road crew. Skydealer also expressed interest in making a big library in close proximity to the museum so maybe that could fit in too somehwere.